Every other month DMRF Canada publishes Going Forward; our bi-monthly e-newsletter.
What's Making News
What is Chucks Run, Walk and Wheel for Dystonia?
The Chuck’s Run, Walk and Wheel 5KM for dystonia is a fun, family-friendly event, hosted at High Park, Toronto on Sunday, June 3, 2018 to raise awareness and funds for dystonia, a neurological movement disorder.
Registration: $39 or you can fundraise $150 and waive your registration fee.
Novel sophisticated research tools are providing investigators new ways to explore the genetics of dystonia. Researchers have the ability to quickly sequence individual genes, analyze whole genomes, and analyze gene expression patterns. Individuals and families who volunteer for genetic studies contribute invaluably to research progress.
A team of investigators led by William Dauer, MD of University of Michigan has made new discoveries about DYT6 dystonia, which affects children. DYT6 dystonia occurs when the body cannot properly produce a protein called THAP1, whose role and function in cells is unknown. Using a mouse model, Dr. Dauer and colleagues discovered that THAP1 is essential for myelination, a process during brain development that forms a protective coating around neurons.
DMRF and Cure Dystonia Now jointly supported a research investigation to explore whether a drug called AZD1446 could potentially provide relief for dystonia patients with fewer side effects than existing medications. Although AZD1446 did not demonstrate therapeutic effects in animal and cell models of DYT1 dystonia, the investigation produced important findings.